Accueil > Médecine > What’s in Placebos : Who Knows ?
What’s in Placebos : Who Knows ?
mercredi 20 octobre 2010
PMID- 20956710
OWN - NLM
STAT- In-Data-Review
DA - 20101019
IS - 1539-3704 (Electronic)
IS - 0003-4819 (Linking)
VI - 153
IP - 8
DP - 2010 Oct 19
TI - What’s in Placebos : Who Knows ? Analysis of Randomized, Controlled Trials.
PG - 532-5
AB -
Background :
No regulations govern placebo composition.
The composition of placebos can influence trial outcomes and merits reporting.
Purpose :
To assess how often investigators specify the composition of placebos in randomized, placebo-controlled trials. Data Sources : 4 English-language general and internal medicine journals with high impact factors. Study
Selection :
3 reviewers screened titles and abstracts of the journals to identify randomized, placebo-controlled trials published from January 2008 to December 2009.
Data Extraction :
Reviewers independently abstracted data from the introduction and methods sections of identified articles, recording treatment type (pill, injection, or other) and whether placebo composition was stated. -Discrepancies were resolved by consensus.
Data Synthesis :
Most studies did not disclose the composition of the study placebo. -Disclosure was less common for pills than for injections and other treatments (8.2% vs. 26.7% ; P = 0.002).
Limitation :
Journals with high impact factors may not be representative.
Conclusion :
Placebos were seldom described in randomized, controlled trials of pills or capsules.
Because the nature of the placebo can influence trial outcomes, placebo formulation should be disclosed in reports of placebo-controlled trials.
Primary Funding Source :
University of California Foundation Fund 3929-Medical Reasoning.
AD - the University of California, San Diego, School of Medicine, San Diego,
California ; McMaster University, Hamilton, Ontario, Canada ; and Centre for
Evidence-Based Medicine, University of Oxford, Oxford, United Kingdom.
FAU - Golomb, Beatrice A
AU - Golomb BA
FAU - Erickson, Laura C
AU - Erickson LC
FAU - Koperski, Sabrina
AU - Koperski S
FAU - Sack, Deanna
AU - Sack D
FAU - Enkin, Murray
AU - Enkin M
FAU - Howick, Jeremy
AU - Howick J
LA - eng
PT - Journal Article
PL - United States
TA - Ann Intern Med
JT - Annals of internal medicine
JID - 0372351
SB - AIM
SB - E
SB - IM
EDAT- 2010/10/20 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/10/20 06:00
AID - 153/8/532 [pii]
AID - 10.1059/0003-4819-153-8-201010190-00010 [doi]
PST - ppublish
SO - Ann Intern Med. 2010 Oct 19 ;153(8):532-5.
Voir en ligne : http://www.ncbi.nlm.nih.gov/pubmed/...