TAG 2 : La Transformation Atypique de Grade 2

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• 1. TAG 2 : La Transformation Atypique de Grade 2, 25 juin 2006, 17:08, par BlueGYN

  2/Transformation atypique de grade 2

   Zone acidophile,

   avec support congestif,

   avec orifices glandulaires,

   iodo négative,

   à contours flous.

  Lorsque les zones rouges l’emportent sur les zones acidophiles, on passe du stade A au stade B avec une signification plus péjorative.

  Correspondances histologiques :

   il s’agit habituellement d’une dysplasie de haut grade et si la biopsie est rassurante,

   il faut se méfier d’un prélèvement en dehors du site dysplasique.

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  Colposcopie après un frottis anormal

  Jean-Luc Leroy Professeur de gynécologie obstétrique, Université de Lille II. Chef de service, Hôpital Jeanne de Flandre, CHU de Lille

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  Voir en ligne : Colposcopie après un frottis anormal

• 2. TAG 2 : La Transformation Atypique de Grade 2, 25 juin 2006, 21:20, par BlueGYN

  A. acetowhite epithelium

  After the application of a dilute solution of acetic acid, areas of high nuclear density appear white. Although this may occur in cases of immature metaplasia, generally the denser the acetowhite change, the faster the change becomes apparent, and the increased length of time the epithelium holds the change, the more severe the lesion may be. Dense acetowhite change within columnar epithelium may indicate glandular disease.

  B. Punctation

  A focal colposcopic pattern in which capillaries appear in a stippled pattern. The finer the punctation appearance, the more likely the lesion is to be of low grade or metaplasia. The coarser the punctation, the more likely the lesion is to be of major grade.

  C. Mosaic

  A focal colposcopic appearance in which the new vessel formation appears as a rectangular pattern like a mosaic. The smaller the mosaic, the more likely the lesion is to be of low grade or metaplasia. The coarser, wider, and more irregular the mosaic, the more likely the lesion is to be of major grade.

  D. Iodine negativity

  After the application of Lugol’s iodine, mature squamous epithelium, which contains glycogen, will stain a deep brown. Iodine negative areas may represent immature metaplasia, cervical intraepithelial neoplasia, or low estrogen states (ie, atrophy). A speckled appearance in an area with slight acetowhite change may represent immature metaplasia or low grade intraepithelial neoplasia. Complete iodine negativity, a yellow staining in an area that has appeared strongly acetowhite, is highly suggestive of high-grade intraepithelial neoplasia.

  E. Atypical vessels

  A focal abnormal colposcopic pattern in which the blood vessel pattern appears not as punctation or mosaic or as the finely branching capillaries of a normal epithelium, but rather as irregular vessels with an abrupt and interrupted course appearing as commas, corkscrew capillaries, or spaghetti-like forms.

  Voir en ligne : Abnormal colposcopic findings

  • 1. TAG 2 : La Transformation Atypique de Grade 2, 21 mars 2009, 22:55, par BlueGYN

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